Efficient Synthesis of Polyfunctionalized Pyrimidine Derivatives

Abstract

A simple and direct procedure was developed for the synthesis of a novel series of polyfunctionalized pyrimidines. They were prepared via reaction of N-(substituted carbamothioyl)benzimidamides (prepared from the reaction of benzimidamide hydrochloride and isothiocyanates) and malononitrile in the presence of CuBr/Et₃N in DMF at 80 °C.

Key words

pyrimidines - heterocycles - isothiocyanates - malononitrile

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