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Synthesis 2017; 49(01): 188-194
DOI: 10.1055/s-0035-1561615
DOI: 10.1055/s-0035-1561615
paper
Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides
Further Information
Publication History
Received: 01 March 2016
Accepted after revision: 14 March 2016
Publication Date:
27 April 2016 (online)
Dedicated to Professor Dieter Enders on the occasion of his 70th birthday and in recognition of his outstanding contribution to asymmetric catalysis.
Abstract
An efficient protocol for chromium(III)-catalyzed C(sp2)–C(sp3) cross-coupling is reported. The alkylations of halo-quinoline and phenacyl derivatives proceed at room temperature within minutes using the tetrahydrofuran-soluble chromium(III) complex CrCl3·3THF. The reactions occur without the formation of homo-coupling side products, which are common for the related iron-, cobalt- or manganese-catalyzed cross-coupling reactions.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561615.
- Supporting Information
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