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Synthesis 2017; 49(01): 188-194
DOI: 10.1055/s-0035-1561615
DOI: 10.1055/s-0035-1561615
paper
Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides
Further Information
Publication History
Received: 01 March 2016
Accepted after revision: 14 March 2016
Publication Date:
27 April 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201701/lookinside/thumbnails/ss-2016-t0152-op_10-1055_s-0035-1561615-1.jpg)
Dedicated to Professor Dieter Enders on the occasion of his 70th birthday and in recognition of his outstanding contribution to asymmetric catalysis.
Abstract
An efficient protocol for chromium(III)-catalyzed C(sp2)–C(sp3) cross-coupling is reported. The alkylations of halo-quinoline and phenacyl derivatives proceed at room temperature within minutes using the tetrahydrofuran-soluble chromium(III) complex CrCl3·3THF. The reactions occur without the formation of homo-coupling side products, which are common for the related iron-, cobalt- or manganese-catalyzed cross-coupling reactions.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561615.
- Supporting Information
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