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Synthesis 2017; 49(01): 87-95
DOI: 10.1055/s-0035-1561665
DOI: 10.1055/s-0035-1561665
paper
Biology-Oriented Synthesis of 3,3-Spiro(2-tetrahydrofuranyl)oxindoles
Further Information
Publication History
Received: 26 April 2016
Accepted after revision: 19 May 2016
Publication Date:
07 June 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201701/lookinside/thumbnails/ss-2016-z0290-op_10-1055_s-0035-1561665-1.jpg)
Dedicated to Prof. Dieter Enders on the occasion of his 70th birthday
Abstract
A biology-oriented synthesis of 3,3-spiro(2-tetrahydrofuranyl)oxindole derivatives is realized through the rhodium(II)-catalyzed three-component reaction of diazoamides, aldehydes and β-nitrostyrenes. The reactions are conducted under mild conditions and the products are obtained in moderate to good yields with excellent regio- and diastereoselectivity.
Key words
biology-oriented synthesis - spirooxindoles - multicomponent reactions - cycloaddition - rhodium - carbonyl ylidesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561665.
- Supporting Information
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