Biology-Oriented Synthesis of 3,3-Spiro(2-tetrahydrofuranyl)oxindoles

Dedicated to Prof. Dieter Enders on the occasion of his 70^th birthday

Abstract

A biology-oriented synthesis of 3,3-spiro(2-tetrahydrofuranyl)oxindole derivatives is realized through the rhodium(II)-catalyzed three-component reaction of diazoamides, aldehydes and β-nitrostyrenes. The reactions are conducted under mild conditions and the products are obtained in moderate to good yields with excellent regio- and diastereoselectivity.

Key words

biology-oriented synthesis - spirooxindoles - multicomponent reactions - cycloaddition - rhodium - carbonyl ylides

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