Easy Synthesis of Two Positional Isomeric Tetrazole Libraries

Abstract

A fast and efficient synthesis of libraries of positional isomeric 1H-tetrazoles and 5H-tetrazoles, for the purpose of testing binding hypothesis of isomeric tetrazoles in fragment-based drug discovery, is described.

Key words

1H-tetrazole - 5H-tetrazole - cyanoacetamide - isocyano­acetamide - [2+3] cycloaddition - Oliveri-Mandala and Alagna reaction - fragment-based drug discovery

• References

• 1 These authors contributed equally to this article.
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