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Synthesis 2016; 48(21): 3701-3712
DOI: 10.1055/s-0035-1562435
DOI: 10.1055/s-0035-1562435
paper
Easy Synthesis of Two Positional Isomeric Tetrazole Libraries
Further Information
Publication History
Received: 04 April 2016
Accepted after revision: 03 May 2016
Publication Date:
21 June 2016 (online)
Abstract
A fast and efficient synthesis of libraries of positional isomeric 1H-tetrazoles and 5H-tetrazoles, for the purpose of testing binding hypothesis of isomeric tetrazoles in fragment-based drug discovery, is described.
Key words
1H-tetrazole - 5H-tetrazole - cyanoacetamide - isocyanoacetamide - [2+3] cycloaddition - Oliveri-Mandala and Alagna reaction - fragment-based drug discoverySupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562435.
- Supporting Information
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References
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