Synthesis of Tröger’s Base Analogues via a Phase-Transfer-Catalyzed Double Aza-Michael Reaction under Base-Free Conditions

Abstract

The potential of phase-transfer catalysis in the synthesis of Tröger’s base analogues via a double aza-Michael addition has been evaluated. It has been observed that no external base is required and PTC may significantly enhance the efficiency of the process or control the selectivity.

Key words

Tröger’s base - double aza-Michael addition - phase-transfer catalysis - base-free - organic synthesis

• References

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