Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitro­anthranilate

Abstract

A novel method for the synthesis of anthranilate esters is described. The esterification reaction of nitro-substituted anthranilic acids was carried out under microwave irradiation. A range of solvents and other reaction parameters were investigated to provide the most environmentally friendly reaction conditions. The feasibility of scale-up was demonstrated, allowing a simple and inexpensive production of anthranilate esters.

Key words

microwave chemistry - green solvent - sustainable chemistry - one-pot reactions - hydrolysis

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