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Synthesis 2016; 48(22): 3924-3930
DOI: 10.1055/s-0035-1562490
DOI: 10.1055/s-0035-1562490
paper
Direct Access to 1,3,5-Trisubstituted 1H-1,2,4-Triazoles from N-Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles
Weitere Informationen
Publikationsverlauf
Received: 11. April 2016
Accepted after revision: 17. Mai 2016
Publikationsdatum:
28. Juni 2016 (online)
Abstract
A copper-catalyzed formation of C–N/N–N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environmentally benign with a large substrate scope available and represents an economical path for numerous C–N/N–N bond formations.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562490.
- Supporting Information
-
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