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Synthesis 2016; 48(22): 3951-3956
DOI: 10.1055/s-0035-1562491
DOI: 10.1055/s-0035-1562491
paper
Construction of the Core Structure of Trichotomone
Further Information
Publication History
Received: 01 April 2016
Accepted after revision: 16 May 2016
Publication Date:
29 June 2016 (online)
Abstract
The catecholic ketal core substructure of trichotomone, a dimeric abietane-type diterpenoid, was constructed. Key elements of the synthesis include an Ullmann condensation between a phenol and phenyl bromide, and the final 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated oxidative dearomatization/ketalization reaction.
Key words
total synthesis - diterpenoid - abietane - Ullman condensation - oxidative dearomatization.Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562491.
- Supporting Information
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