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Synlett 2016; 27(17): 2485-2488
DOI: 10.1055/s-0035-1562517
DOI: 10.1055/s-0035-1562517
letter
Hydrogen Peroxide Promoted Metal-Free Oxidation/Cyclization of α-Hydroxy N-Arylamides: A Facile One-Pot Synthesis of Isatins
Weitere Informationen
Publikationsverlauf
Received: 27. Mai 2016
Accepted after revision: 23. Juni 2016
Publikationsdatum:
25. Juli 2016 (online)
Abstract
A novel, efficient, and environmentally friendly method was developed for converting α-hydroxy N-arylamides into isatins (1H-indole-2,3-diones) by using hydrogen peroxide as oxidant. The reactions proceeded smoothly under metal-free conditions and generated the corresponding products in good to excellent yields. This method has advantages of a broad substrate scope and simple operations.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562517.
- Supporting Information
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