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Synlett 2016; 27(16): 2314-2326
DOI: 10.1055/s-0035-1562784
DOI: 10.1055/s-0035-1562784
account
Introduction of Functionalized Difluoromethylated Building Blocks Mediated or Catalyzed by Copper
Weitere Informationen
Publikationsverlauf
Received: 02. Juni 2016
Accepted after revision: 17. Juni 2016
Publikationsdatum:
20. Juli 2016 (online)
![](https://www.thieme-connect.de/media/synlett/201616/lookinside/thumbnails/st-2016-a0376-a_10-1055_s-0035-1562784-1.jpg)
Abstract
This account summarizes our recent progress on the copper-catalyzed direct introduction of functionalized difluoromethylated building blocks, and more particularly, the CF2CO2Et motif. We also discuss how this work led us to develop new copper-mediated methodologies to introduce the CF2PO(OR)2 motif, a valuable phosphate bioisostere.
1 Introduction
2 Copper-Catalyzed Introduction of the CF2CO2Et Residue
3 New Developments Toward the Introduction of the CF2PO(OEt)2 Motif
4 Conclusion and Outlook
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For selected reviews, see:
For recent reviews, see:
For recent reviews, see:
For related papers from our group reporting the use of BrCF2CO2Et, see:
For selected examples, see:
For selected references from our group, see:
For selected examples, see:
For examples of α-selectivity, see:
For examples and discussion regarding the α/β selectivity, see:
For a review, see:
For related procedures, see:
For selected recent examples, see:
For selected examples, see: