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DOI: 10.1055/s-0035-1564798
Imaging Evaluation of Hemophilia: Musculoskeletal Approach
Publication History
Publication Date:
19 October 2015 (online)
Abstract
Imaging assessment is an important tool to evaluate clinical joint outcomes of hemophilia. Arthropathic changes have traditionally been evaluated by plain radiography and more recently by ultrasound and magnetic resonance imaging (MRI). Early arthropathic changes can be identified by modern imaging techniques such as T2 mapping MRI of cartilage even before clinical symptoms become apparent. Cross-sectional imaging modalities such as CT, ultrasonography, and MRI are useful in assessing bleeding-related musculoskeletal complications such as pseudotumors that still exist in some parts of the world. This article provides an overview of imaging of hemophilic arthropathy, and discusses the role and scope of individual imaging modalities currently in use in clinical practice, as well as of promising techniques that require further investigation in the immediate future.
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References
- 1 De Palma AF, Cotler JM. Hemophilic arthropathy. AMA Arch Surg 1956; 72 (2) 247-250
- 2 Wood K, Omer A, Shaw MT. Haemophilic arthropathy. A combined radiological and clinical study. Br J Radiol 1969; 42 (499) 498-505
- 3 Arnold WD, Hilgartner MW. Hemophilic arthropathy. Current concepts of pathogenesis and management. J Bone Joint Surg Am 1977; 59 (3) 287-305
- 4 Pettersson H, Ahlberg A, Nilsson IM. A radiologic classification of hemophilic arthropathy. Clin Orthop Relat Res 1980; (149) 153-159
- 5 Rodriguez-Merchan EC, de la Corte H. Musculoskeletal outcomes research in haemophilia. In: Rodriguez-Merchan EC, ed. The Haemophilic Joints. New Perspectives. Oxford, UK: Blackwell Publishing; 2003: 36-44
- 6 Erlemann R, Rosenthal H, Walthers EM, Almeida P, Calleja R. Reproducibility of the Pettersson scoring system. An interobserver study. Acta Radiol 1989; 30 (2) 147-151
- 7 Takedani H, Fujii T, Kobayashi Y, Haga N, Tatsunami S, Fujii T. Inter-observer reliability of three different radiographic scores for adult haemophilia. Haemophilia 2011; 17 (1) 134-138
- 8 Luck Jr JV, Silva M, Rodriguez-Merchan EC, Ghalambor N, Zahiri CA, Finn RS. Hemophilic arthropathy. J Am Acad Orthop Surg 2004; 12 (4) 234-245
- 9 Silva M, Luck Jr JV, Quon D , et al. Inter- and intra-observer reliability of radiographic scores commonly used for the evaluation of haemophilic arthropathy. Haemophilia 2008; 14 (3) 504-512
- 10 Doria AS, Babyn PS, Lundin B , et al; Expert MRI Working Group of the International Prophylaxis Study Group. Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the International Prophylaxis Study Group. Haemophilia 2006; 12 (5) 503-513
- 11 Doria AS. State-of-the-art imaging techniques for the evaluation of haemophilic arthropathy: present and future. Haemophilia 2010; 16 (Suppl. 05) 107-114
- 12 Lundin B, Berntorp E, Pettersson H , et al. Gadolinium contrast agent is of limited value for magnetic resonance imaging assessment of synovial hypertrophy in hemophiliacs. Acta Radiol 2007; 48 (5) 520-530
- 13 Kulkarni MV, Drolshagen LF, Kaye JJ , et al. MR imaging of hemophiliac arthropathy. J Comput Assist Tomogr 1986; 10 (3) 445-449
- 14 Nuss R, Kilcoyne RF, Geraghty S , et al. MRI findings in haemophilic joints treated with radiosynoviorthesis with development of an MRI scale of joint damage. Haemophilia 2000; 6 (3) 162-169
- 15 Lundin B, Pettersson H, Ljung R. A new magnetic resonance imaging scoring method for assessment of haemophilic arthropathy. Haemophilia 2004; 10 (4) 383-389
- 16 Doria AS, Lundin B, Kilcoyne RF , et al. Reliability of progressive and additive MRI scoring systems for evaluation of haemophilic arthropathy in children: expert MRI Working Group of the International Prophylaxis Study Group. Haemophilia 2005; 11 (3) 245-253
- 17 Lundin B, Babyn P, Doria AS , et al; International Prophylaxis Study Group. Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy. Haemophilia 2005; 11 (2) 109-115
- 18 Doria AS, Lundin B, Miller S , et al; Expert Imaging Working Group of The International Prophylaxis Study Group. Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children. Haemophilia 2008; 14 (2) 303-314
- 19 Lundin B, Manco-Johnson ML, Ignas DM , et al; International Prophylaxis Study Group. An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group. Haemophilia 2012; 18 (6) 962-970
- 20 Chan MW, Leckie A, Xavier F , et al. A systematic review of MR imaging as a tool for evaluating haemophilic arthropathy in children. Haemophilia 2013; 19 (6) e324-e334
- 21 Foppen W, van der Schaaf IC, Witkamp TD, Fischer K. Is joint effusion on MRI specific for haemophilia?. Haemophilia 2014; 20 (4) 582-586
- 22 Rubin JM, Bude RO, Carson PL, Bree RL, Adler RS. Power Doppler US: a potentially useful alternative to mean frequency-based color Doppler US. Radiology 1994; 190 (3) 853-856
- 23 Kilcoyne RF, Lundin B, Pettersson H. Evolution of the imaging tests in hemophilia with emphasis on radiography and magnetic resonance imaging. Acta Radiol 2006; 47 (3) 287-296
- 24 Acharya SS, Schloss R, Dyke JP , et al. Power Doppler sonography in the diagnosis of hemophilic synovitis—a promising tool. J Thromb Haemost 2008; 6 (12) 2055-2061
- 25 Zukotynski K, Jarrin J, Babyn PS , et al. Sonography for assessment of haemophilic arthropathy in children: a systematic protocol. Haemophilia 2007; 13 (3) 293-304
- 26 Keshava S, Gibikote S, Mohanta A, Doria AS. Refinement of a sonographic protocol for assessment of haemophilic arthropathy. Haemophilia 2009; 15 (5) 1168-1171
- 27 Melchiorre D, Linari S, Innocenti M , et al. Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score. Haemophilia 2011; 17 (1) 112-117
- 28 Martinoli C, Della Casa Alberighi O, Di Minno G , et al. Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US). Thromb Haemost 2013; 109 (6) 1170-1179
- 29 Xavier F, Zhang N, Mohanta M , et al. Sonography for assessment of elbows in haemophilic children: a systematic protocol. Rheumatology Curr Res 2012; (Suppl. 02) 1-9
- 30 Klukowska A, Czyrny Z, Laguna P, Brzewski M, Serafin-Krol MA, Rokicka-Milewska R. Correlation between clinical, radiological and ultrasonographical image of knee joints in children with haemophilia. Haemophilia 2001; 7 (3) 286-292
- 31 Muça-Perja M, Riva S, Grochowska B, Mangiafico L, Mago D, Gringeri A. Ultrasonography of haemophilic arthropathy. Haemophilia 2012; 18 (3) 364-368
- 32 Doria AS, Keshava SN, Mohanta A , et al. Diagnostic accuracy of ultrasound for assessment of hemophilic arthropathy. MRI correlation. AJR Am J Roentgenol 2015; 204 (3) W336-W347
- 33 Querol F, Rodriguez-Merchan EC. The role of ultrasonography in the diagnosis of the musculo-skeletal problems of haemophilia. Haemophilia 2012; 18 (3) e215-e226
- 34 Daly BD, McPhillips M, Leung AW, Evans RM, Metreweli C. Ultrasound, computed tomography and magnetic resonance in the investigation of iliopsoas compartment disease. Australas Radiol 1992; 36 (4) 294-299
- 35 Balkan C, Kavakli K, Karapinar D. Iliopsoas haemorrhage in patients with haemophilia: results from one centre. Haemophilia 2005; 11 (5) 463-467
- 36 Rodriguez Merchan EC. The haemophilic pseudotumour. Int Orthop 1995; 19 (4) 255-260
- 37 Rodriguez-Merchan EC, Jimenez-Yuste V, Aznar JA , et al. Joint protection in haemophilia. Haemophilia 2011; 17 (Suppl. 02) 1-23
- 38 Kraft J, Blanchette V, Babyn P , et al. Magnetic resonance imaging and joint outcomes in boys with severe hemophilia A treated with tailored primary prophylaxis in Canada. J Thromb Haemost 2012; 10 (12) 2494-2502
- 39 Shergill AK, Sussman MS, Castro D, Man C, Mohanta A, Doria AS. Implementation of Novel Ultra-Short TE (UTE) and Conventional Imaging Techniques for Assessment of Blood Degradation Products in Hemophiliac Joints—Work in Progress. Proceedings of the 2014 Radiological Society of North America Scientific Assembly, Chicago, IL
- 40 Soliman MM, Bouskill V, Mohanta A, Zhang N, Zhou A, Doria AS. Challenges of Point of Care Ultrasound (POC-US) in Evaluating Hemophilic Arthropathy—Preliminary Experience. Proceedings of the 2015 Radiological Society of North America Scientific Assembly, Chicago, IL
- 41 Raffini L, Manno C. Modern management of haemophilic arthropathy. Br J Haematol 2007; 136 (6) 777-787
- 42 Das B. Role of radiosynovectomy in the treatment of rheumatoid arthritis and hemophilic arthropathies. Biomed Imaging Interv J 2007; 3 (4) e45
- 43 Hermann G, Gilbert MS, Abdelwahab IF. Hemophilia: evaluation of musculoskeletal involvement with CT, sonography, and MR imaging. AJR Am J Roentgenol 1992; 158 (1) 119-123
- 44 Park JS, Ryu KN. Hemophilic pseudotumor involving the musculoskeletal system: spectrum of radiologic findings. AJR Am J Roentgenol 2004; 183 (1) 55-61
- 45 Yang BT, Wang YZ, Wang XY, Wang ZC. Imaging features of paediatric haemophilic pseudotumour of the maxillary bone: report of three cases and review of the literature. Br J Radiol 2012; 85 (1016) 1107-1111
- 46 Kumar R, Pruthi RK, Kobrinsky N, Shaughnessy WJ, McKusick MA, Rodriguez V. Pelvic pseudotumor and pseudoaneurysm in a pediatric patient with moderate hemophilia B: successful management with arterial embolization and surgical excision. Pediatr Blood Cancer 2011; 56 (3) 484-487
- 47 Doria AS, Chaudry GA, Nasui C , et al. The use of parallel imaging for MRI assessment of knees in children and adolescents. Pediatr Radiol 2010; 40 (3) 284-293
- 48 Spannow AH, Pfeiffer-Jensen M, Andersen NT, Herlin T, Stenbøg E. Ultrasonographic measurements of joint cartilage thickness in healthy children: age- and sex-related standard reference values. J Rheumatol 2010; 37 (12) 2595-2601
- 49 Panghaal V, Janow G, Trinh A, Ilowite N, Levin TL. Normal epiphyseal cartilage measurements in the knee in children: an alternative sonographic approach. J Ultrasound Med 2012; 31 (1) 49-53
- 50 Spannow AH, Stenboeg E, Pfeiffer-Jensen M , et al. Ultrasound and MRI measurements of joint cartilage in healthy children: a validation study. Ultraschall Med 2011; 32 (Suppl. 01) S110-S116
- 51 Keshava S, Gibikote S, Mohanta A, Blanchette V, Srivastava A, Doria AS. Ultrasound and MRI of growing joints in healthy boys: correlation with ex-vivo phantom measurements [Abstract]. Proceedings of the 56th Annual Meeting of the Society for Pediatric Radiology, 2013, San Antonio, TX
- 52 Doria AS, Crawley A, Babyn P , et al. BOLD MRI at 1.5 Tesla in juvenile idiopathic arthritis: preliminary experience. Clinics (Sao Paulo) 2013; 68 (5) 721-724
- 53 Doria AS, Amirabadi A, Miller E, Cheng H-L, Zhong A, Sussman MS. Functional-Molecular Magnetic Resonance Imaging for Early Characterization of Hemophilic Arthropathy in a Rabbit Model [Abstract]. Proceedings of the XXIX International Congress of the World Federation of Hemophilia, 2010, Buenos Aires, Argentina
- 54 Agarwal V, Kumar M, Singh JK, Rathore RK, Misra R, Gupta RK. Diffusion tensor anisotropy magnetic resonance imaging: a new tool to assess synovial inflammation. Rheumatology (Oxford) 2009; 48 (4) 378-382
- 55 Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 1997; 205 (2) 551-558
- 56 Macwan K, Amirabadi A, Miller E, Gahunia H, Zhong A, Doria AS. T1 and T2 Maps as Surrogate Imaging Techniques for Physiologic Characterization of Cartilage Damage in a Rabbit Model if Hemophilic Arthropathy [Abstract]. Proceedings of the 96th Scientific Assembly and Annual Meeting of the Radiological Society of North America, 2010, Chicago, IL
- 57 Kim HK, Laor T, Graham TB , et al. T2 relaxation time changes in distal femoral articular cartilage in children with juvenile idiopathic arthritis: a 3-year longitudinal study. AJR Am J Roentgenol 2010; 195 (4) 1021-1025
- 58 Schmitt B, Zbýn S, Stelzeneder D , et al. Cartilage quality assessment by using glycosaminoglycan chemical exchange saturation transfer and (23)Na MR imaging at 7 T. Radiology 2011; 260 (1) 257-264
- 59 Doria AS, Zhang N, Lundin B , et al. Quantitative versus semiquantitative MR imaging of cartilage in blood-induced arthritic ankles: preliminary findings. Pediatr Radiol 2014; 44 (5) 576-586
- 60 Chan MW, Amirabadi A, Man C, Mohanta A, Fenster A, Doria AS. Techniques and Challenges of 3D Ultrasound and Fusion 3DUS-MR Imaging for Assessment of Knees in Juvenile Idiopathic Arthritis [Abstract]. Proceedings of the 98th Scientific Assembly and Annual Meeting of the Radiological Society of North America, 2012, Chicago, IL
- 61 Doria AS, Karshafian R, Moineddin R , et al. Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis. Pediatr Radiol 2006; 36 (12) 1242-1251
- 62 Shammas A, Doria AS, Charron M, Zhong A, Amirabadi A, Metser U. [18-F] Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) for Detection of Hemophilic Arthropathy in a Rabbit Model [Abstract]. Proceedings of the 57th Annual Meeting of the Society of Nuclear Medicine, 2010, Salt Lake City, UT
- 63 Borrero CG, Mountz JM, Mountz JD. Emerging MRI methods in rheumatoid arthritis. Nat Rev Rheumatol 2011; 7 (2) 85-95