DOI: 10.1055/s-00000077

Seminars in Thrombosis and Hemostasis

Issue 08 · Volume 41 · November 2015 DOI: 10.1055/s-005-30366 Current Issues in Hemophilia: Recognizing Clinical Heterogeneity, Replacement Therapy and Outcome Assessment Guest Editor: Alok Srivastava, MD, FRACP, FRCPA, FRCP.

Editorial

809
Favaloro, Emmanuel J.: 2015 Eberhard F. Mammen Award Announcements: Part II—Young Investigator Awards

Preface

816
Srivastava, Alok: Current Issues in Hemophilia: Recognizing Clinical Heterogeneity, Replacement Therapy, and Outcome Assessment

819
Blanchette, Victor S.; Srivastava, Alok: Definitions in Hemophilia: Resolved and Unresolved Issues
826
Nogami, Keiji; Shima, Midori: Phenotypic Heterogeneity of Hemostasis in Severe Hemophilia
832
Blobel, Carl P.; Haxaire, Coline; Kalliolias, George D.; DiCarlo, Edward; Salmon, Jane; Srivastava, Alok: Blood-Induced Arthropathy in Hemophilia: Mechanisms and Heterogeneity
838
Peyvandi, Flora; Garagiola, Isabella: Treatment of Hemophilia in the Near Future
849
Hubbard, Anthony R.: Potency Labeling of Novel Factor VIII and Factor IX Concentrates: Past Experience and Current Strategy
855
van den Berg, H. Marijke; Peyvandi, Flora: Assessment of Clotting Factor Concentrates—Pivotal Studies and Long-Term Requirements
860
Fischer, Kathelijn; Berntorp, Erik: Targeting Factor Replacement Therapy in Severe Hemophilia: Which Level Is Important?
864
Carcao, Manuel D.; Iorio, Alfonso: Individualizing Factor Replacement Therapy in Severe Hemophilia
872
Poonnoose, Pradeep M.; van der Net, Janjaap: Musculoskeletal Outcome in Hemophilia: Bleeds, Joint Structure and Function, Activity, and Health-Related Fitness
880
Keshava, Shyamkumar N.; Gibikote, Sridhar; Doria, Andrea S.: Imaging Evaluation of Hemophilia: Musculoskeletal Approach
894
David, Judy Ann; Feldman, Brian M.: Assessing Activities, Participation, and Quality of Life in Hemophilia: Relevance, Current Limitations, and Possible Options
903
Kubisz, Peter; Mikovic, Danijela; Stanciakova, Lucia; Sinzinger, Helmut: Meeting Report: 18th International Meeting of the Danubian League against Thrombosis and Haemorrhagic Disorders

Letter to the Editor

901
Stanciakova, Lucia; Simurda, Tomas; Stasko, Jan; Snahnicanova, Zuzana; Loderer, Dusan; Lasabova, Zora; Kubisz, Peter: Novel Fibrinogen Bbeta Chain Mutation as an Underlying Mechanism of Afibrinogenemia?