Diabetologie und Stoffwechsel 2016; 11 - P80
DOI: 10.1055/s-0036-1580827

Differential associations between inflammation-related biomarkers and depressive symptoms in individuals with recently diagnosed type 1 and type 2 diabetes

JF Fürstos 1, 2, C Herder 2, 3, B Nowotny 2, 3, A Begun 1, 2, K Strassburger 2, 4, K Müssig 2, 3, 5, J Szendroedi 2, 3, 5, A Icks 1, 2, 6 M Roden 2, 3, 5, GDS group
  • 1German Diabetes Center, Paul Langerhans Group for Health Services Research, Düsseldorf, Germany
  • 2German Center for Diabetes Research (DZD), München-Neuherberg, Germany
  • 3German Diabetes Center, Institute for Clinical Diabetology, Düsseldorf, Germany
  • 4German Diabetes Center, Institute for Biometrics and Epidemiology, Düsseldorf, Germany
  • 5Medical Faculty, Heinrich Heine University Düsseldorf, Department of Endocrinology and Diabetology, Düsseldorf, Germany
  • 6Medical Faculty, Heinrich Heine University Düsseldorf, Institute for Health Services Research and Health Economics, Düsseldorf, Germany

Aims: Depressive disorders represent a common comorbidity of both type 1 diabetes (T1D) and type 2 diabetes (T2D). Inflammation-related processes have been implicated in both development of diabetes and depression. This study aimed to investigate whether biomarkers of inflammation were associated with depressive symptoms in individuals with diabetes and if such associations differed by diabetes type.

Methods: This study is based on 139 individuals with T1D (60% men, mean age 36 years) and 295 individuals with T2D (67% men, mean age 53 years) who participated in the baseline examination of the German Diabetes Study. The main inclusion criterion was a known disease duration of < 1 year. Depressive symptoms were assessed with the ADS-L (Allgemeine Depressionsskala-Langversion) questionnaire. Associations between the ADS-L as continuous score and biomarkers of inflammation were assessed using multiple linear regression models adjusting for age, sex, body mass index, HbA1c, lipids, hypertension, medication and comorbidities.

Results: Serum high-sensitivity C-reactive protein (hsCRP) and the ratio of high-molecular-weight/total adiponectin were positively associated with ADS-L in T2D (both p < 0.01), but not in T1D. In contrast, serum levels of soluble intercellular adhesion molecule (sICAM)-1 were positively associated with ADS-L only in T1D (p = 0.035), but not in T2D. P values for interaction between 0.035 and 0.099 indicated differences between diabetes types. No associations were observed for interleukin (IL)-6, IL-18 and soluble E-selectin.

Conclusion: Biomarkers of subclinical inflammation and endothelial activation are differentially associated with depressive symptoms in individuals with recently diagnosed diabetes. Our data indicate that associations differ between diabetes types.