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Semin Neurol 2016; 36(04): 397-404
DOI: 10.1055/s-0036-1585096
DOI: 10.1055/s-0036-1585096
Review Article
Dementia
Further Information
Publication History
Publication Date:
19 September 2016 (online)
Abstract
Dementia often is defined as a progressive cognitive disturbance leading to a loss of independent function. Most clinicians are familiar with the typical pattern of amnestic Alzheimer's disease, the most common neurodegenerative presentation of dementia. Atypical dementia presentations, including atypical Alzheimer's variants, however, may pose a diagnostic challenge for even experienced clinicians. In this article the authors discuss clinical “pearls” for the diagnosis of various neurodegenerative dementia syndromes. When considering the causes of dementia, the mnemonic VITAMINS can be helpful in considering various etiologies.
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References
- 1 Galasko D. The diagnostic evaluation of a patient with dementia. Continuum (Minneap Minn) 2013; 19 (2 Dementia): 397-410
- 2 Alzheimer's Association. 2015 Alzheimer's disease facts and figures. Alzheimers Dement 2015; 11 (3) 332-384
- 3 McKhann GM, Knopman DS, Chertkow H , et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7 (3) 263-269
- 4 Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol 2009; 66 (2) 216-225
- 5 Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev 2015; 4: CD006489
- 6 Migliaccio R, Agosta F, Possin KL , et al. Mapping the progression of atrophy in early- and late-onset Alzheimer's disease. J Alzheimers Dis 2015; 46 (2) 351-364
- 7 Ossenkoppele R, Pijnenburg YA, Perry DC , et al. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain 2015; 138 (Pt 9): 2732-2749
- 8 Crutch SJ, Lehmann M, Schott JM, Rabinovici GD, Rossor MN, Fox NC. Posterior cortical atrophy. Lancet Neurol 2012; 11 (2) 170-178
- 9 Berg D, Postuma RB, Adler CH , et al. MDS research criteria for prodromal Parkinson's disease. Mov Disord 2015; 30 (12) 1600-1611
- 10 McKeith IG, Dickson DW, Lowe J , et al; Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65 (12) 1863-1872
- 11 Lim SM, Katsifis A, Villemagne VL , et al. The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. J Nucl Med 2009; 50 (10) 1638-1645
- 12 Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl DE. Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 2001; 50 (3) 358-365
- 13 Graff-Radford J, Murray ME, Lowe VJ , et al. Dementia with Lewy bodies: basis of cingulate island sign. Neurology 2014; 83 (9) 801-809
- 14 Guidi M, Paciaroni L, Paolini S, De Padova S, Scarpino O. Differences and similarities in the neuropsychological profile of dementia with Lewy bodies and Alzheimer's disease in the early stage. J Neurol Sci 2006; 248 (1–2) 120-123
- 15 McKeith I, Del Ser T, Spano P , et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 2000; 356 (9247) 2031-2036
- 16 Rascovsky K, Hodges JR, Knopman D , et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011; 134 (Pt 9): 2456-2477
- 17 Lomen-Hoerth C, Anderson T, Miller B. The overlap of amyotrophic lateral sclerosis and frontotemporal dementia. Neurology 2002; 59 (7) 1077-1079
- 18 Mendez MF, Shapira JS, McMurtray A, Licht E. Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia. Am J Geriatr Psychiatry 2007; 15 (1) 84-87
- 19 Litvan I, Agid Y, Calne D , et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 1996; 47 (1) 1-9
- 20 Kim YE, Kang SY, Ma HI, Ju YS, Kim YJ. A visual rating scale for the hummingbird sign with adjustable diagnostic validity. J Parkinsons Dis 2015; 5 (3) 605-612
- 21 Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol 2009; 8 (3) 270-279
- 22 Armstrong MJ, Litvan I, Lang AE , et al. Criteria for the diagnosis of corticobasal degeneration. Neurology 2013; 80 (5) 496-503
- 23 Lee SE, Rabinovici GD, Mayo MC , et al. Clinicopathological correlations in corticobasal degeneration. Ann Neurol 2011; 70 (2) 327-340
- 24 Gorno-Tempini ML, Hillis AE, Weintraub S , et al. Classification of primary progressive aphasia and its variants. Neurology 2011; 76 (11) 1006-1014
- 25 Geschwind MD, Shu H, Haman A, Sejvar JJ, Miller BL. Rapidly progressive dementia. Ann Neurol 2008; 64 (1) 97-108
- 26 Sala I, Marquié M, Sánchez-Saudinós MB , et al. Rapidly progressive dementia: experience in a tertiary care medical center. Alzheimer Dis Assoc Disord 2012; 26 (3) 267-271
- 27 Papageorgiou SG, Kontaxis T, Bonakis A, Karahalios G, Kalfakis N, Vassilopoulos D. Rapidly progressive dementia: causes found in a Greek tertiary referral center in Athens. Alzheimer Dis Assoc Disord 2009; 23 (4) 337-346
- 28 Rabinovici GD, Wang PN, Levin J , et al. First symptom in sporadic Creutzfeldt-Jakob disease. Neurology 2006; 66 (2) 286-287
- 29 Paterson RW, Takada LT, Geschwind MD. Diagnosis and treatment of rapidly progressive dementias. Neurol Clin Pract 2012; 2 (3) 187-200
- 30 Takada LT, Geschwind MD. Prion diseases. Semin Neurol 2013; 33 (4) 348-356
- 31 Geschwind MD. Prion diseases. Continuum (Minneap Minn) 2015; 21 (6 Neuroinfectious Disease): 1612-1638
- 32 Carswell C, Thompson A, Lukic A , et al. MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease. BMC Neurol 2012; 12 (1) 153
- 33 Geschwind MK, Kuryan C, Cattaruzza T , et al. Brain MRI in sporadic Jakob-Creutzfeldt disease is often misread. Neurology 2010; 74 (Suppl. 02) A213
- 34 Vitali P, Migliaccio R, Agosta F, Rosen HJ, Geschwind MD. Neuroimaging in dementia. Semin Neurol 2008; 28 (4) 467-483