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Journal of Pediatric Neurology 2016; 14(02): 057-062
DOI: 10.1055/s-0036-1586728
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Effects of Antiepileptic Drugs on Oxidative Stress Enzymes in Children with Epilepsy: Correlation with Child Psychopathology

Riad M. Elsayed
1   Pediatric Neurology Unit, Department of Pediatrics, Mansoura University, Mansoura, Dakahlia, Egypt
,
Rania H. Shatla
2   Pediatric Neurology Unit, Department of Pediatrics, Ain Shams University, Cairo, Egypt
,
Hala E. Sayyah
3   Department of Psychiatry, Beni Suef University, Beni Suef Governorate, Egypt
,
Soheir S. Korraa
4   National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
,
Atef Elmogy
5   Pediatric Nephrology Unit, Department of Pediatrics, Mansoura University, Mansoura, Egypt
› Author Affiliations
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Publication History

12 February 2016

25 June 2016

Publication Date:
08 August 2016 (online)

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Abstract

Antiepileptic drugs (AEDs) used in children may affect the oxidative status and child psychopathology. Our study conducted to investigate the possible causal–effect relationship between commonly used AEDs, oxidative stress enzymes, and child psychopathology. Overall, 84 children with epilepsy, and 42 controls were assessed by child behavioral checklist and blood level of oxidative stress enzymes before and after 6 months use of AEDs. We reported significant statistical difference between patients before and after therapy regarding attention problems (p-value < 0.001) and motor excess hyperactivity (p-value < 0.01). On the other hand, there were no significant statistical differences regarding the level of all oxidative stress enzymes after treatment. In conclusion, AEDs alter child psychopathology by another mechanism rather than changing oxidative stress enzymes.

Keywords

oxidative stress - child psychopathology - antiepileptics
 

  • References

  • 1 Sobaniec W, Solowiej E, Kulak W, Bockowski L, Smigielska-Kuzia J, Artemowicz B. Evaluation of the influence of antiepileptic therapy on antioxidant enzyme activity and lipid peroxidation in erythrocytes of children with epilepsy. J Child Neurol 2006; 21 (7) 558-562
    CrossrefPubMedGoogle Scholar
  • 2 Cengiz M, Yüksel A, Seven M. The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children. Pharmacol Res 2000; 41 (4) 423-425
    CrossrefPubMedGoogle Scholar
  • 3 Sołowiej E, Sobaniec W. The effect of antiepileptic drug therapy on antioxidant enzyme activity and serum lipid peroxidation in young patients with epilepsy [in Polish]. Neurol Neurochir Pol 2003; 37 (5) 991-1003
    PubMedGoogle Scholar
  • 4 Bolayir E, Celik K, Tas A, Topaktas S, Bakir S. The effects of oxcarbazepine on oxidative stress in epileptic patients. Methods Find Exp Clin Pharmacol 2004; 26 (5) 345-348
    CrossrefPubMedGoogle Scholar
  • 5 Erakovic V, Zupan G, Varljen J, Laginja J, Simonic A. Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures. Epilepsia 2001; 42 (2) 181-189
    PubMedGoogle Scholar
  • 6 Rauca C, Zerbe R, Jantze H. Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling. Brain Res 1999; 847 (2) 347-351
    CrossrefPubMedGoogle Scholar
  • 7 Bruce AJ, Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic Biol Med 1995; 18 (6) 993-1002
    CrossrefPubMedGoogle Scholar
  • 8 Rodenburg R, Stams GJ, Meijer AM, Aldenkamp AP, Deković M. Psychopathology in children with epilepsy: a meta-analysis. J Pediatr Psychol 2005; 30 (6) 453-468
    CrossrefPubMedGoogle Scholar
  • 9 Reilly C, Kent E, Neville BGR. Psychopathology in childhood epilepsy: a review. Child Adolesc Ment Health 2013; 18 (2) 65-75
    CrossrefPubMedGoogle Scholar
  • 10 Achenbach TM, Dumenci L. Advances in empirically based assessment: revised cross-informant syndromes and new DSM-oriented scales for the CBCL, YSR, and TRF: comment on Lengua, Sadowksi, Friedrich, and Fischer (2001). J Consult Clin Psychol 2001; 69 (4) 699-702
    CrossrefPubMedGoogle Scholar
  • 11 Achenbach TM, Dumenci L, Rescorla LA. DSM-oriented and empirically based approaches to constructing scales from the same item pools. J Clin Child Adolesc Psychol 2003; 32 (3) 328-340
    CrossrefPubMedGoogle Scholar
  • 12 Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70 (1) 158-169
    PubMedGoogle Scholar
  • 13 Minami M, Yoshikawa H. A simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta 1979; 92 (3) 337-342
    CrossrefPubMedGoogle Scholar
  • 14 Johansson LH, Borg LA. A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem 1988; 174 (1) 331-336
    CrossrefPubMedGoogle Scholar
  • 15 Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982; 126 (1) 131-138
    CrossrefPubMedGoogle Scholar
  • 16 Yagi K. Assay for serum lipid peroxide level and its clinical significance. In: Yagi KJ, ed. Lipid Peroxide in Biology and Medicine. New York, NY: Academic Press; 1982: 223-242
    CrossrefGoogle Scholar
  • 17 Hermann B, Whitman S. Psychopathology in epilepsy. The role of psychology in altering paradigms of research, treatment, and prevention. Am Psychol 1992; 47 (9) 1134-1138
    CrossrefPubMedGoogle Scholar
  • 18 Hermann BP, Whitman S. Behavioral and personality correlates of epilepsy: a review, methodological critique, and conceptual model. Psychol Bull 1984; 95 (3) 451-497
    CrossrefPubMedGoogle Scholar
  • 19 Austin JK, Harezlak J, Dunn DW, Huster GA, Rose DF, Ambrosius WT. Behavior problems in children before first recognized seizures. Pediatrics 2001; 107 (1) 115-122
    CrossrefPubMedGoogle Scholar
  • 20 DuPaul GJ, McGoey KE, Mautone JA. Pediatric pharmacology and psychopharmacology. In: Roberts MC, ed. Handbook of Pediatric Psychology. New York, NY: Guilford Press; 2003: 234-250
    Google Scholar
  • 21 Austin JK, Dunn DW, Johnson CS, Perkins SM. Behavioral issues involving children and adolescents with epilepsy and the impact of their families: recent research data. Epilepsy Behav 2004; 5 (Suppl. 03) S33-S41
    CrossrefPubMedGoogle Scholar
  • 22 Pianta RC, Lothman DJ. Predicting behavior problems in children with epilepsy: child factors, disease factors, family stress, and child-mother interaction. Child Dev 1994; 65 (5) 1415-1428
    CrossrefPubMedGoogle Scholar
  • 23 Stores G, Williams PL, Styles E, Zaiwalla Z. Psychological effects of sodium valproate and carbamazepine in epilepsy. Arch Dis Child 1992; 67 (11) 1330-1337
    CrossrefPubMedGoogle Scholar
  • 24 Williams J, Bates S, Griebel ML , et al. Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes?. Epilepsia 1998; 39 (10) 1064-1069
    CrossrefPubMedGoogle Scholar
  • 25 Dunn DW, Austin JK, Huster GA. Behaviour problems in children with new-onset epilepsy. Seizure 1997; 6 (4) 283-287
    CrossrefPubMedGoogle Scholar
  • 26 Grosso S, Longini M, Rodriguez A , et al. Oxidative stress in children affected by epileptic encephalopathies. J Neurol Sci 2011; 300 (1–2) 103-106
    CrossrefPubMedGoogle Scholar
  • 27 Arhan E, Serdaroglu A, Ozturk B , et al. Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy. Seizure 2011; 20 (2) 138-142
    CrossrefPubMedGoogle Scholar
  • 28 Yiş U, Seçkin E, Kurul SH, Kuralay F, Dirik E. Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. Epilepsy Res 2009; 84 (2–3) 232-237
    CrossrefPubMedGoogle Scholar
  • 29 Yüksel A, Cengiz M, Seven M, Ulutin T. Changes in the antioxidant system in epileptic children receiving antiepileptic drugs: two-year prospective studies. J Child Neurol 2001; 16 (8) 603-606
    CrossrefPubMedGoogle Scholar
  • 30 Michoulas A, Tong V, Teng XW, Chang TKH, Abbott FS, Farrell K. Oxidative stress in children receiving valproic acid. J Pediatr 2006; 149 (5) 692-696
    CrossrefPubMedGoogle Scholar
  • 31 Verrotti A, Scardapane A, Franzoni E, Manco R, Chiarelli F. Increased oxidative stress in epileptic children treated with valproic acid. Epilepsy Res 2008; 78 (2–3) 171-177
    CrossrefPubMedGoogle Scholar
  • 32 Trimble MR. New antiepileptic drugs and psychopathology. Neuropsychobiology 1998; 38 (3) 149-151
    CrossrefPubMedGoogle Scholar
  • 33 Aldenkamp AP, Alpherts WCJ, Sandstedt P , et al. Antiepileptic drug-related cognitive complaints in seizure-free children with epilepsy before and after drug discontinuation. Epilepsia 1998; 39 (10) 1070-1074
    CrossrefPubMedGoogle Scholar
  • 34 Mandelbaum DE, Burack GD. The effect of seizure type and medication on cognitive and behavioral functioning in children with idiopathic epilepsy. Dev Med Child Neurol 1997; 39 (11) 731-735
    PubMedGoogle Scholar