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Journal of Pediatric Neurology 2016; 14(02): 057-062
DOI: 10.1055/s-0036-1586728
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Effects of Antiepileptic Drugs on Oxidative Stress Enzymes in Children with Epilepsy: Correlation with Child Psychopathology

Riad M. Elsayed
1   Pediatric Neurology Unit, Department of Pediatrics, Mansoura University, Mansoura, Dakahlia, Egypt
,
Rania H. Shatla
2   Pediatric Neurology Unit, Department of Pediatrics, Ain Shams University, Cairo, Egypt
,
Hala E. Sayyah
3   Department of Psychiatry, Beni Suef University, Beni Suef Governorate, Egypt
,
Soheir S. Korraa
4   National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
,
Atef Elmogy
5   Pediatric Nephrology Unit, Department of Pediatrics, Mansoura University, Mansoura, Egypt
› Author Affiliations
Further Information

Publication History

12 February 2016

25 June 2016

Publication Date:
08 August 2016 (online)

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Abstract

Antiepileptic drugs (AEDs) used in children may affect the oxidative status and child psychopathology. Our study conducted to investigate the possible causal–effect relationship between commonly used AEDs, oxidative stress enzymes, and child psychopathology. Overall, 84 children with epilepsy, and 42 controls were assessed by child behavioral checklist and blood level of oxidative stress enzymes before and after 6 months use of AEDs. We reported significant statistical difference between patients before and after therapy regarding attention problems (p-value < 0.001) and motor excess hyperactivity (p-value < 0.01). On the other hand, there were no significant statistical differences regarding the level of all oxidative stress enzymes after treatment. In conclusion, AEDs alter child psychopathology by another mechanism rather than changing oxidative stress enzymes.

Keywords

oxidative stress - child psychopathology - antiepileptics