Synlett 2017; 28(05): 601-606
DOI: 10.1055/s-0036-1588361
letter
© Georg Thieme Verlag Stuttgart · New York

Rapid Ligand-Free Base-Accelerated Copper-Catalyzed Homocoupling Reaction of Arylboronic Acids

Ya-Nan Cao
a   School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. of China
b   Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. of China   eMail: gaofeng@sicau.edu.cn   eMail: xxbiochem@163.com
,
Xin-Chuan Tian
b   Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. of China   eMail: gaofeng@sicau.edu.cn   eMail: xxbiochem@163.com
,
Xing-Xiu Chen
b   Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. of China   eMail: gaofeng@sicau.edu.cn   eMail: xxbiochem@163.com
,
Yun-Xin Yao
b   Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. of China   eMail: gaofeng@sicau.edu.cn   eMail: xxbiochem@163.com
,
Feng Gao*
a   School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. of China
b   Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. of China   eMail: gaofeng@sicau.edu.cn   eMail: xxbiochem@163.com
,
Xian-Li Zhou*
a   School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. of China
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Publikationsverlauf

Received: 19. August 2016

Accepted after revision: 30. Oktober 2016

Publikationsdatum:
17. November 2016 (online)


Abstract

A rapid, ligand-free, base-accelerated, copper-catalyzed homocoupling reaction of (het)arylboronic acids is presented. A ­CuCl2·2H2O/Na2CO3-based catalyst enabled the formation of bi(het)aryl compounds by a homocoupling process in moderate to excellent yields (72–97%) within 15 minutes. A mechanism for the copper-catalyzed base-accelerated reaction is proposed.

Supporting Information