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Synlett 2017; 28(20): 2886-2890
DOI: 10.1055/s-0036-1588516
DOI: 10.1055/s-0036-1588516
letter
Copper-Mediated Synthesis of Monofluoro Aryl Acetates via Decarboxylative Cross-Coupling
Further Information
Publication History
Received: 27 May 2017
Accepted after revision: 03 July 2017
Publication Date:
08 August 2017 (online)


Dedicated to Victor Snieckus on the occasion of his 80th birthday.
Abstract
We report the Cu-promoted oxidative cross-coupling of α-fluoromalonate half-esters and aryl boron reagents to deliver monofluoro α-aryl acetates under mild conditions (in air at room temperature). The reaction uses a simple, readily available monofluorinated building block to generate arylated compounds with functional groups that are not easily tolerated by existing methods, such as aryl bromides, iodides, pyridines, and pyrimidines.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588516.
- Supporting Information