Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans

Dedicated to Prof. Dieter Enders on the occasion of his 70^th birthday

Abstract

Here, we report the catalytic trifluoromethylthiolation of furans employing sodium chloride as an inexpensive, abundant and ecologically friendly catalyst. The developed method exhibits perfect regio­selectivity and a high functional group tolerance. Furthermore, the robustness of the newly developed method was determined by the additive­-based Robustness Screen.

Key words

trifluoromethylthiolation - sodium chloride - bioactive compounds - heterocycles - synthetic methods

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