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Synlett 2017; 28(08): 924-928
DOI: 10.1055/s-0036-1588689
DOI: 10.1055/s-0036-1588689
letter
Tuning the Properties of Penetrating Peptides by Oxime Conjugation
Weitere Informationen
Publikationsverlauf
Received: 14. Oktober 2016
Accepted after revision: 20. Dezember 2016
Publikationsdatum:
25. Januar 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201708/lookinside/thumbnails/st-2016-b0695-l_10-1055_s-0036-1588689-1.jpg)
Abstract
We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehicles.
Key words
peptide chemistry - penetrating peptides - supramolecular chemistry - membrane transport - solid-phase peptide synthesisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588689.
- Supporting Information
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