o-Phenylenediacetic Acid Anhydride in the Castagnoli–Cushman Reaction: Extending the Product Space to ε-Lactams

Abstract

The diversity of lactam products accessible by the Castagnoli–Cushman reaction (CCR) of imines and dicarboxylic acid anhydrides has been extended to privileged ε-lactams. This novel variant of the CCR using o-phenylenediacetic anhydride is often high-yielding and remarkably diastereoselective and allows the use of α-C–H imines.

Key words

multicomponent reactions - Castagnoli–Cushman reaction - seven-membered rings

• References and Notes

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