Synlett 2017; 28(14): 1845-1851
DOI: 10.1055/s-0036-1588829
letter
© Georg Thieme Verlag Stuttgart · New York

Copper-Mediated Direct Sulfenylation of 4-Hydroxyquinolinones and 4-Hydroxypyridones with Aryl Thiols via a C−H Functionalization Process

Tao Guo*
a   School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. of China   eMail: taoguo@haut.edu.cn
b   School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, P. R. of China
,
Hongyan Wang
a   School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. of China   eMail: taoguo@haut.edu.cn
› Institutsangaben
Gefördert durch: Doctor Fund of Henan University of Technology 2013BS053
Gefördert durch: Colleges and Universities Key Research Program Foundation of Henan Province 17A150006
Gefördert durch: Science Foundation Of Henan University of Technology 2015QNJH08
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Publikationsverlauf

Received: 12. März 2017

Accepted after revision: 18. April 2017

Publikationsdatum:
04. Mai 2017 (online)


Abstract

An efficient approach for the direct sulfanylation of 4-hydroxyquinolinones and 4-hydroxypyridones with aryl thiols in the presence of CuI/DMSO has been developed. The substrate scope is broad, allowing facile synthesis of a range of structurally diverse 3-sulfanyl-4-hydroxyquinolinones and 3-sulfanyl-4-hydroxypyridones in good efficiency.

Supporting Information