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Synthesis 2017; 49(01): 96-114
DOI: 10.1055/s-0036-1588878
DOI: 10.1055/s-0036-1588878
paper
Total Synthesis of Lycopalhine A
Further Information
Publication History
Received: 26 July 2016
Accepted after revision: 09 August 2016
Publication Date:
14 September 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201701/lookinside/thumbnails/ss-2016-c0526-op_10-1055_s-0036-1588878-1.jpg)
Dedicated to Professor Dieter Enders on the occasion of his 70th birthday
Abstract
The total synthesis of lycopalhine A featuring the construction of a tricyclic system via cleavage of a cyclopropane ring and an ensuing intramolecular Michael addition, stereoselective introduction of a 2-aminoethyl moiety via a reaction of allyltrimethylsilane with a sulfonyliminium ion, and a stereoselective intramolecular aldol reaction is reported.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588878.
- Supporting Information
-
References
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For reviews of the lycopodium alkaloids, see:
For recent syntheses of the fawcettimine-type lycopodium alkaloids, see: