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Synlett 2017; 28(07): 863-867
DOI: 10.1055/s-0036-1588931
DOI: 10.1055/s-0036-1588931
letter
Iron(III) Chloride Promoted Oxidative Radical Cyclization for the Synthesis of Lactams Having a Quaternary Carbon
Further Information
Publication History
Accepted: 16 November 2016
Received after revision: 19 December 2016
Publication Date:
12 January 2017 (online)
Abstract
The oxidative radical cyclization of active methylene derivatives containing allyl groups as radical acceptors proceeded with the use of FeCl3 as a mild oxidant. The FeCl3-promoted cyclization reactions of α-substituted active methylene compounds provide a synthetic approach to various γ-lactams containing a quaternary carbon atom.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588931.
- Supporting Information
-
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For reviews, see:
For examples of Mn(III)-promoted reactions, see:
For examples of CAN-promoted reactions, see:
For examples of Fe(III)-mediated radical reactions, see:
For examples of Fe(II)-mediated radical reactions, see:
For Conia–ene-type radical reactions (Type B), see:
For Conia–ene-type radical reaction (Type C), see: