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Synlett 2017; 28(08): 989-993
DOI: 10.1055/s-0036-1588942
DOI: 10.1055/s-0036-1588942
letter
Enantioselective Conjugate Addition of Azlactones to Nitroolefins with a Thiourea-Based Bifunctional Organocatalyst
Further Information
Publication History
Received: 25 October 2016
Accepted after revision: 31 December 2016
Publication Date:
02 February 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201708/lookinside/thumbnails/st-2016-w0722-l_10-1055_s-0036-1588942-1.jpg)
‡ These authors contributed equally to this work.
Abstract
A bifunctional, thiourea-based, cinchona alkaloid derived catalyst showed a high catalytic activity in an enantioselective conjugate addition of azlactones to nitroolefins to give a series of diastereopure N,O-aminals in high yields and with high enantioselectivities. The method provides a potential tool for the stereoselective construction of β-amino acid derivatives.
Key words
enantioselectivity - azlactones - conjugate addition - aminals - asymmetric catalysis - nitroalkenesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588942.
- Supporting Information
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References and Notes
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