Synlett 2017; 28(09): 1087-1090
DOI: 10.1055/s-0036-1588949
letter
© Georg Thieme Verlag Stuttgart · New York

Multicomponent Cascade Synthesis of 1,4-Dihydropyridine Derivatives from Pyridines, Methyl Propiolate, and Aromatic Acids

Panpan Huang
a   Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. of China   eMail: jxhq6200@163.com   eMail: liuliangxian1962@163.com
,
Xiangjun Peng
b   School of Pharmaceutical Science, Gannan Medical University, Ganzhou, Jiangxi 341000, P. R. of China
,
Qing Huang*
a   Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. of China   eMail: jxhq6200@163.com   eMail: liuliangxian1962@163.com
,
Liangxian Liu*
a   Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. of China   eMail: jxhq6200@163.com   eMail: liuliangxian1962@163.com
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Publikationsverlauf

Received: 08. Dezember 2016

Accepted after revision: 22. Januar 2017

Publikationsdatum:
13. Februar 2017 (online)


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Abstract

A metal-free highly efficient synthesis of a wide range of 4-propenyl 1,4-DHPs from pyridines, methyl propiolate, and aromatic acids is described. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope.

Supporting Information