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Synthesis 2017; 49(14): 3157-3164
DOI: 10.1055/s-0036-1589012
DOI: 10.1055/s-0036-1589012
paper
Enantioselective Reduction of 3-Substituted Quinolines with a Cyclopentadiene-Based Chiral Brønsted Acid
We are grateful for the financial support of the National Science Foundation of China (21302116), the Fundamental Research Funds for the Central Universities (GK201703018), and Shaanxi Normal University.Weitere Informationen
Publikationsverlauf
Received: 04. Februar 2017
Accepted after revision: 29. März 2017
Publikationsdatum:
08. Mai 2017 (online)
![](https://www.thieme-connect.de/media/synthesis/201714/lookinside/thumbnails/ss-2017-h0073-op_10-1055_s-0036-1589012-1.jpg)
Abstract
Enantioselective reduction of 3-substituted quinolines has been achieved using a cyclopentadiene-based chiral Brønsted acid as catalyst and Hantzsch ester as hydrogen donor, affording the corresponding tetrahydroquinolines in good enantioselectivities.
Key words
tetrahydroquinolines - transfer hydrogenation - 3-substituted quinolones - enantioselectivity - chiral Brønsted acidSupporting Information
- Supporting information for this article is available online at https://doi.org /10.1055/s-0036-1589012.
- Supporting Information
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