Synlett 2018; 29(05): 597-602
DOI: 10.1055/s-0036-1589139
letter
© Georg Thieme Verlag Stuttgart · New York

Mild and Direct C–H Arylation of Quinoxalin-2(1H)-ones with Aryldiazonium Salts under Metal-Free Conditions

Kun Yin
a   School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. of China
,
a   School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. of China
b   Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. of China   Email: rhzhang@tongji.edu.cn
› Author Affiliations
Financial support from the National Nature Science Foundation of China (20972113/B020502) is gratefully acknowledged.
Further Information

Publication History

Received: 12 September 2017

Accepted after revision: 29 October 2017

Publication Date:
11 December 2017 (online)


Abstract

A mild and direct C–H arylation of quinoxazolin-2(1H)-ones with aryldiazonium salts has been developed. A wide variety of 3-arylquinoxazolin-2(1H)-ones were synthesized in up to 92% yield at room temperature under metal-free conditions. This strategy tolerates a wide range of functional groups and shows environmental friendliness and practicality.

Supporting Information