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Synlett 2017; 28(19): 2539-2555
DOI: 10.1055/s-0036-1590877
DOI: 10.1055/s-0036-1590877
account
Cyclization and Cycloisomerization of π-Tethered Ynamides: An Expedient Synthetic Method to Construct Carbo- and Heterocycles
Further Information
Publication History
Received: 24 May 2017
Accepted after revision: 20 July 2017
Publication Date:
13 September 2017 (online)
Dedicated to Professor S. V. Kessar, Punjab University, India, for his outstanding contribution in the area of synthetic organic chemistry and also on the occasion of his 85th birthday
Abstract
Stable ynamides are used for the development of novel synthetic transformations and the construction of unusual carbo/heterocycles. The intramolecular cyclization of π-tethered alkene/alkyne/allene-ynamides is studied extensively for the fabrication of a wide range of molecular scaffolds for various applications. The ketene-acetal/aminal generated in situ from π-tethered ynamides participates in intramolecular cyclization/cycloisomerization processes to yield N-bearing fused heterocycles. This account summarizes the scientific merits and the advances made in cyclization and cycloisomerization strategies for stable π-tethered alkene/alkyne/allene-ynamides.
1 Introduction
2 π-Tethered Ynamides
3 Alkene-Tethered Ynamides
4 Alkyne-Tethered Ynamides
5 Allene-Tethered Ynamides
6 Concluding Remarks
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