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DOI: 10.1055/s-0036-1590936
Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide
We thank the financial support from National Natural Science Foundation of China (21302150), Hubei Provincial Department of Education (D20131501), Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2012]1707, foundation of Chutian distinguished fellow from Hubei Provincial Department of Education, and the foundation of High-end Talent Cultivation Program from Wuhan Institute of Technology.Publication History
Received: 03 September 2017
Accepted after revision: 25 September 2017
Publication Date:
12 October 2017 (online)
§ These authors contributed equally to this work
Dedicated to Professor Herbert Mayr at Ludwig-Maximilians Universität on the occasion of his 70th birthday.
Abstract
A novel and convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) without the use of sulfurating reagent was explored. In the presence of CuI and di-tert-butyl peroxide (DTBP), various aryl thioamides were prepared with good to excellent yields, tetramethylthiuram disulfide as thioamide source is essential for this transformation. The protocol features broad substrate scope, nice yields, operability and commercially available and inexpensive raw materials, showing its practical synthetic value in organic synthesis.
Key words
aryl thioamide - benzaldehyde - tetramethylthiuram disulfide - copper - di-tert-butyl peroxideSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590936.
- Supporting Information
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