Convenient and Inexpensive Route to Sulfonylated Pyridines via S_NAr Reaction of Electron-Rich Pyridines by Iron Catalysis

Abstract

Sulfonylated pyridines were synthesized in moderate to excellent yields, with a wide scope of substituted pyridines and sulfinate salts as starting materials, by an iron-catalyzed S_NAr reaction. This new methodology exhibits advantages for the synthesis of these useful substrates, such as the use of a readily available, inexpensive catalyst, prevention of the disproportionation of the sulfinate salts, and, more importantly, providing access to electron-rich pyridine substrates.

Key words

sulfinate salts - sulfones - iron catalysis - pyridines - coupling

• References

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