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Synthesis 2018; 50(09): 1914-1920
DOI: 10.1055/s-0036-1591541
DOI: 10.1055/s-0036-1591541
paper
Convenient and Inexpensive Route to Sulfonylated Pyridines via SNAr Reaction of Electron-Rich Pyridines by Iron Catalysis
This work was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada and Le Fonds de Recherche Nature et technologies du Québec (FQRNT). Support was also kindly provided by Centre for Green Chemistry and Catalysis (CGCC), and Concordia University.Further Information
Publication History
Received: 27 November 2017
Accepted after revision: 12 January 2017
Publication Date:
20 February 2018 (online)
Abstract
Sulfonylated pyridines were synthesized in moderate to excellent yields, with a wide scope of substituted pyridines and sulfinate salts as starting materials, by an iron-catalyzed SNAr reaction. This new methodology exhibits advantages for the synthesis of these useful substrates, such as the use of a readily available, inexpensive catalyst, prevention of the disproportionation of the sulfinate salts, and, more importantly, providing access to electron-rich pyridine substrates.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591541.
- Supporting Information
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