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Synlett 2018; 29(10): 1395-1399
DOI: 10.1055/s-0036-1591565
DOI: 10.1055/s-0036-1591565
letter
Copper-Catalyzed Cascade Synthesis of [1,2,4]-Triazoloquinazolinones
Financial support from the National Natural Science Foundation of China (Grant No. 21772108) is gratefully acknowledged.Further Information
Publication History
Received: 04 February 2018
Accepted after revision: 12 March 2018
Publication Date:
20 April 2018 (online)


Abstract
An efficient and practical method for the synthesis of 1,2,4-triazolo[5,1-b]quinazolin-9(3H)-ones has been developed via the copper-catalyzed domino reactions of readily available substituted N′-acetyl-2-bromobenzohydrazides with cyanamide. The protocol uses inexpensive CuI as the catalyst, and no other ligand or additive was required. The target products were prepared in good to excellent yields with tolerance of various functional groups.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591565.
- Supporting Information