Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to α,β-Unsaturated Sulfonamides

Abstract

A pincer palladium-catalyzed asymmetric 1,4-addition of diarylphosphines to α,β-unsaturated sulfonamides was realized for the synthesis of chiral sulfonamide phosphines with up to 98% ee under mild conditions.

Key words

α,β-unsaturated sulfonamides - asymmetric 1,4-addition - pincer palladium catalyst - chiral phosphine

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