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Synthesis 2018; 50(09): 1901-1906
DOI: 10.1055/s-0036-1591769
DOI: 10.1055/s-0036-1591769
paper
Stereoselective Synthesis of Northern Fragment of Eribulin Mesylate from d-Mannose
GV thanks DST New Delhi for INSPIRE Faculty Award (IFA14-CH-158). SC thanks Science and Engineering Research Board, Department of Science and Technology for a research grant (SB/S2/JCB-002/2015). The authors thank Council of Scientific and Industrial Research, Department of Science and Technology, Govt. of India, for research grant.Further Information
Publication History
Received: 14 December 2017
Accepted after revision: 01 February 2018
Publication Date:
21 February 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201809/lookinside/thumbnails/ss-2017-z0816-op_10-1055_s-0036-1591769-1.jpg)
Abstract
Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key steps involved in this synthesis are butyllithium-facilitated coupling between sulfone and aldehyde, then Dess–Martin periodinane oxidation followed by samarium(II) iodide mediated desulfonylation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591769.
- Supporting Information
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