RSS-Feed abonnieren
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1055/s-0037-1607036
Subcutaneous Panniculitis-Like T-Cell Lymphoma Presenting as a Local Inflammation of a Thigh in an 8-Month-Old Child
Publikationsverlauf
20. April 2017
25. Juli 2017
Publikationsdatum:
28. Oktober 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00024358/201701/lookinside/thumbnails/10-1055-s-0037-1607036_170335cr-1.jpg)
Abstract
During infancy, skin inflammation is usually treated in basic pediatric care. In this study, we present a case of an 8-month-old girl with a 2-month history of an inflammation of the thigh treated locally by ointments and oral antibiotics in basic and dermatological care. The patient had a history of fever, sweating, and failure to thrive. The lactate dehydrogenase was elevated up to 869 U/L with low C-reactive protein (1.04 mg/L). Magnetic resonance imaging of the thigh reassured the diagnosis of local inflammation. Intravenous antibiotic caused mild local improvement, but the episodes of high fever sustained. The patient was transferred to our pediatric surgery department for treatment and surgical biopsy of the lesion. Histopathological examination confirmed a subcutaneous panniculitis-like T-cell lymphoma, which is a rare cytotoxic T-cell lymphoma representing less than 1% of non-Hodgkin lymphomas, uncommon in children. The patient was introduced to a chemotherapy protocol EURO-LB 2002 with good response. In a skin lesion that is associated with systemic symptoms and responding untypically to antibiotic treatment malignancy should be considered and biopsy not be postponed.
-
References
- 1 Prindaville B, Antaya RJ, Siegfried EC. Pediatric dermatology: past, present, and future. Pediatr Dermatol 2015; 32 (01) 1-12
- 2 Rayala BZ, Morrell DS. Common skin conditions in children: Neonatal skin lesions. FP Essent 2017; 453: 11-17
- 3 Silverberg NB. A practical overview of pediatric atopic dermatitis, part 3: differential diagnosis, comorbidities, and measurement of disease burden. Cutis 2016; 97 (06) 408-412
- 4 Kawachi Y, Furuta J, Fujisawa Y, Nakamura Y, Ishii Y, Otsuka F. Indolent subcutaneous panniculitis-like T cell lymphoma in a 1-year-old child. Pediatr Dermatol 2012; 29 (03) 374-377
- 5 Go RS, Wester SM. Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma: a systematic analysis of 156 patients reported in the literature. Cancer 2004; 101 (06) 1404-1413
- 6 Swerdlow SH, Campo E, Harris NL. , et al. WHO classification of tumours of haematopoetic and lymphoid tissues. 4th ed. Lyon, France: International Agency for Research on Cancer (IARC); 2008
- 7 Gupta V, Arava S, Bakhshi S, Vashisht KR, Reddy R, Gupta S. Subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic syndrome in a child. Pediatr Dermatol 2016; 33 (02) e72-e76
- 8 Huppmann AR, Xi L, Raffeld M, Pittaluga S, Jaffe ES. Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: a lymphoma of low malignant potential. Pediatr Blood Cancer 2013; 60 (07) 1165-1170