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Synlett 2018; 29(14): 1847-1850
DOI: 10.1055/s-0037-1609573
DOI: 10.1055/s-0037-1609573
letter
Transition-Metal-Free Efficient Synthesis of Bisindole Sulfanes Using 2-(Fluorosulfonyl)difluoroacetic Acid
Authors
We are grateful for the financial support by the National Natural Science Foundation of China (21503610, 21502109), The Natural Science Foundation of Shaanxi Province (No. 2017JQ2017), Key Research & Development Project of Shaanxi Province (2017ZDXM-GY-040), and the Doctoral Scientific Research Foundation of Xi’an Polytechnic University (107020336).
Weitere Informationen
Publikationsverlauf
Received: 21. März 2018
Accepted after revision: 13. Juni 2018
Publikationsdatum:
20. Juli 2018 (online)
Abstract
By using 2-(fluorosulfonyl)difluoroacetic acid as sulfur reagent, bisindole sulfanes were highly efficient synthesized under transition-metal-free conditions. Results indicate that this proceeded not at the relatively acidic C-2 position but rather selectively at the nucleophilic C-3 position to give the desired compounds with excellent regioselectivities and good yields.
Key words
synthesis - indoles - 2-(fluorosulfonyl)difluoroacetic acid - sulfur reagent - bisindole sulfanesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609573.
- Supporting Information (PDF)
-
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