Palladium-Catalyzed Decarboxylative N-3-ortho-C–H Acylation of 1,4-Disubstituted 1,2,3-Triazoles with α-Oxocarboxylic Acids

Xinyuan Ma; Hongtai Huang; Jianhua Yang; Xuepu Feng; Kai Xie

doi:10.1055/s-0037-1609729

Synthesis, Table of Contents

Synthesis 2018; 50(13): 2567-2576
DOI: 10.1055/s-0037-1609729

paper

Palladium-Catalyzed Decarboxylative N-3-ortho-C–H Acylation of 1,4-Disubstituted 1,2,3-Triazoles with α-Oxocarboxylic Acids

Xinyuan Ma

Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China Email: hmxiekai@163.com

,

Hongtai Huang

Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China Email: hmxiekai@163.com

,

Jianhua Yang

Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China Email: hmxiekai@163.com

,

Xuepu Feng

Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China Email: hmxiekai@163.com

,

Kai Xie*

Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China Email: hmxiekai@163.com

› Author Affiliations

Abstract

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Abstract

An efficient palladium-catalyzed decarboxylative selective C–H acylation is reported using α-oxocarboxylic acids as the acyl source directed by 1,2,3-triazole ring. This method provides a novel access to various 1,2,3-triazole derivatives bearing diaryl ketone skeleton.

Key words

decarboxylation - acylation - palladium - C–H activation - 1,4-disubstituted 1,2,3-triazole

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References

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