Highly Efficient Coupling of Unstable Bicyclic Pyrimidines and Pyrazoles under Basic Conditions, and its Application to the Synthesis of Pharmaceutical Compounds

Abstract

The efficient Pd-catalyzed coupling of unstable bicyclic pyrimidines and pyrazoles under basic conditions was established for the first time. The reactions proceeded with excellent yields without hydrolysis using Pd₂(dba)₃, ^t BuXPhos, and K₃PO₄.

Key words

Pd-catalyzed coupling - bicyclic pyrimidine - bicyclic pyridine - pyrazole - ^t BuXPhos

• References and Notes

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