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Synthesis 2018; 50(21): 4165-4188
DOI: 10.1055/s-0037-1609932
DOI: 10.1055/s-0037-1609932
review
Recent Advances in Copper(II)-Mediated or -Catalyzed C–H Functionalization
We gratefully acknowledge the financial support from the ‘Thousand Youth Talents Plan’, the National Natural Sciences Foundation of China (No. 21672235), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000), the ‘Shanghai Rising-Star Plan’ (No. 15QA1404600), CAS Key Laboratory of Synthetic Chemistry of Natural Substances and Shanghai Institute of Organic Chemistry.Weitere Informationen
Publikationsverlauf
Received: 22. Mai 2018
Accepted after revision: 29. Juni 2018
Publikationsdatum:
20. September 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201821/lookinside/thumbnails/ss-2018-h0358-r_10-1055_s-0037-1609932-1.jpg)
Abstract
This review summarizes recent developments in the field of copper-mediated or -catalyzed C–H functionalization. The substrate scope has been expanded from the C–H activation of aryls to more challenging alkyls. Furthermore, catalytic amounts of copper salt are sufficient to promote the challenging C–H functionalization in some cases, which represents the focus of future research.
1 Introduction
2 C–C Bond Formation
3 C–N Bond Formation
4 C–O Bond Formation
5 C–Halogen Bond Formation
6 C–S Bond Formation
7 Conclusions and Outlook
-
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