Recent Advances in Copper(II)-Mediated or -Catalyzed C–H 
Functionalization

Zhao-Kun Li; Xue-Shun Jia; Liang Yin

doi:10.1055/s-0037-1609932

Synthesis, Inhaltsverzeichnis

Synthesis 2018; 50(21): 4165-4188
DOI: 10.1055/s-0037-1609932

review

Recent Advances in Copper(II)-Mediated or -Catalyzed C–H Functionalization

Zhao-Kun Li

^aDepartment of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. of China eMail: xsjia@mail.shu.edu.cn

^bCAS Key Laboratory of Synthetic Chemistry of Natural Substances, Centre for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China eMail: liangyin@sioc.ac.cn

,

Xue-Shun Jia*

^aDepartment of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. of China eMail: xsjia@mail.shu.edu.cn

,

Liang Yin *

^bCAS Key Laboratory of Synthetic Chemistry of Natural Substances, Centre for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China eMail: liangyin@sioc.ac.cn

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Abstract

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Abstract

This review summarizes recent developments in the field of copper-mediated or -catalyzed C–H functionalization. The substrate scope has been expanded from the C–H activation of aryls to more challenging alkyls. Furthermore, catalytic amounts of copper salt are sufficient to promote the challenging C–H functionalization in some cases, which represents the focus of future research.

1 Introduction

2 C–C Bond Formation

3 C–N Bond Formation

4 C–O Bond Formation

5 C–Halogen Bond Formation

6 C–S Bond Formation

7 Conclusions and Outlook

Key words

C–H activation - C–H functionalization - directing group - copper

Volltext

Referenzen

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