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Synlett 2018; 29(12): 1552-1571
DOI: 10.1055/s-0037-1610126
DOI: 10.1055/s-0037-1610126
account
Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions
Further Information
Publication History
Received: 10 March 2018
Accepted after revision: 05 April 2018
Publication Date:
16 May 2018 (online)
Abstract
This account describes our group’s latest research in the field of diversity-oriented synthesis of natural products via gold-catalyzed cascade reactions. We present two general strategies based on gold-catalyzed cycloisomerization: a gold-catalyzed cascade reaction of 1,7-diynes and a pinacol-terminated gold-catalyzed cascade reaction. We highlight our development of synthetic methods for the construction of biologically active natural products by using these two strategies.
1 Introduction
2 Gold-Catalyzed Cascade Reactions of 1,7-Diynes
2.1 Collective Synthesis of C15 Oxygenated Drimane-Type Sesquiterpenoids
2.2 Synthesis of Left-Wing Fragment of Azadirachtin I
2.3 Collective Synthesis of Cladiellins
3 Pinacol-Terminated Gold-Catalyzed Cascade Reaction
3.1 Asymmetric Formal Total Synthesis of (+)-Cortistatins
3.2 Total Synthesis of Orientalol F
3.3 Asymmetric Total Synthesis of (–)-Farnesiferol C
4 Summary and Outlook
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For a review, see:
For selected examples for synthetic studies, see:
For reviews, see:
For reviews on the synthesis of the cortistatins, see: