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Synthesis 2018; 50(24): 4883-4888
DOI: 10.1055/s-0037-1610238
DOI: 10.1055/s-0037-1610238
paper
Synthesis of Spiro Barbiturates and Meldrum’s Acid Derivatives via a [2+2+2] Cyclotrimerization
S.K. thanks Department of Science and Technology for the award of a J. C. Bose fellowship and Praj Industries for the award of chair professor (Green Chemistry). G.S. thanks the CSIR-New Delhi for the award of research fellowship. We also thank DST, New Delhi for the financial support.Weitere Informationen
Publikationsverlauf
Received: 30. Mai 2018
Accepted after revision: 19. Juli 2018
Publikationsdatum:
14. August 2018 (online)
Abstract
Intermolecular [2+2+2] cycloaddition of propargyl halides with 1,6-diynes was accomplished with a catalytic amount of Mo(CO)6 to generate benzyl halo barbiturates and Meldrum’s acid derivatives containing a spiro linkage. Furthermore, we have extended this methodology to synthesize linearly fused Meldrum’s acid derivatives via Diels–Alder reaction using rongalite chemistry.
Key words
barbituric acid - Meldrum’s acid - [2+2+2] cycloaddition - Mo(CO)6 - spirocycles - benzyl halides - Diels–AlderSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610238.
- Supporting Information
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