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Synlett 2018; 29(20): 2601-2607
DOI: 10.1055/s-0037-1610256
DOI: 10.1055/s-0037-1610256
synpacts
Asymmetric Construction of Halogenated Cyclic Quaternary Carbon Center through Enolate Activation of Aldehydes
We are grateful for the financial support from the NSFC (21502009, 21702021 and 81573588), the Science & Technology Department of Sichuan Province (2017JQ0032), ‘Thousand Talents Program’ of Sichuan Province, ‘Chengdu Talents Program’, and the Start-up Fund of Chengdu University.Further Information
Publication History
Received: 04 June 2018
Accepted after revision: 27 July 2018
Publication Date:
31 August 2018 (online)
Abstract
The construction of a chiral halogenated cyclic quaternary carbon center through various catalytic strategies is an emerging hot topic in the field of asymmetric synthesis. Herein, we give a summary of recently developed synthetic methods for preparing such structures. In addition, a novel enolate activation mode of aldehydes is highlighted, which provides an elegant pathway to access enantiopure heterocycles featuring a halogenated quaternary stereocenter through organocatalytic [4+2] cycloaddition.
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