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Synlett 2019; 30(02): 124-128
DOI: 10.1055/s-0037-1610335
DOI: 10.1055/s-0037-1610335
synpacts
Manganese(I)-Catalyzed Selective Functionalization of Alkynes
We gratefully acknowledge financial support from the National Natural Science Foundation of China (21702098, 21672099 and 21732003), the Fundamental Research Funds for the Central Universities (No. 020514380158, 020514380131), the ‘1000-Youth Talents Plan’ and the program A for Outstanding PhD candidate of Nanjing University (201802A018).Weitere Informationen
Publikationsverlauf
Received: 16. Oktober 2018
Accepted after revision: 25. Oktober 2018
Publikationsdatum:
30. November 2018 (online)
Abstract
Mn(I)-catalyzed selective functionalization of alkynes permits the convenient synthesis of substituted alkenes with high step and atom economies. Although the insertion of five-membered chelated manganacycle intermediates into alkynes has been widely reported, nonchelated Ar–Mn(I) species originating from commercially available arylboronic acids are unprecedented. Our new protocol achieved a challenging hydroarylation of unsymmetrical 1,3-diynes with arylboronic acids with complete regio-, stereo-, and chemoselectivity to give a wide array of trisubstituted conjugated (Z)-enynes in moderate to good yields.
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For selected metal-catalyzed hydroarylations with ArB(OH)2, see: