Potassium Alkoxide/Disilane-Mediated Dehalogenative Deuteration

Xin Wang; Ming-Hui Zhu; Wen-Bo Liu

doi:10.1055/s-0037-1610699

Synlett, Table of Contents

Synlett 2019; 30(09): 1003-1007
DOI: 10.1055/s-0037-1610699

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Potassium Alkoxide/Disilane-Mediated Dehalogenative Deuteration

Xin Wang

,

Ming-Hui Zhu

,

Wen-Bo Liu*

Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, 299 Bayi Rd, Wuhan, Hubei, 430072, P. R. of China Email: wenboliu@whu.edu.cn

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Abstract

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Abstract

Deuterated compounds are of great importance in chemistry and pharmaceuticals. Reductive dehalogenation is one of the most useful methods to incorporate deuterium into molecules. This article briefly discusses the historical development of dehalogenative deuteration reactions that involve transition-metal catalysis, radical halogen abstraction, alkali-metal reductive deuteration, and the recently developed potassium methoxide/hexamethyldisilane-mediated dehalogenation of aryl halides.

Key words

deuteration - dehalogenation - aryl halides - Transition-metal-free - potassium base - disilane

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References

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