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Synthesis 2019; 51(20): 3875-3882
DOI: 10.1055/s-0037-1610725
DOI: 10.1055/s-0037-1610725
paper
Synthesis of Asymmetrical 2,6-Diarylpyridines from Linear α,β,γ,δ-Unsaturated Ketones by Addition of Ammonium Formate Followed by Annulation
Further Information
Publication History
Received: 05 June 2019
Accepted after revision: 24 July 2019
Publication Date:
08 August 2019 (online)


In memory of Professor Yongmin Zhang (1932–2019)
Abstract
A simple and efficient method has been established for the synthesis of asymmetrical 2,6-diarylpyridines by cyclization of α,β,γ,δ-unsaturated ketones with ammonium formate under air atmosphere. The reaction is metal-free and operationally convenient from readily available starting materials. Thirty-three examples have been presented, most of which show good yields.
Key words
regioselectivity - Michael addition - annulations - 2,4-dien-1-one - asymmetrical pyridineSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610725.
- Supporting Information